The Brigham and Women's Hospital, Inc.

Giorgio Giatsidis

Dennis Paul Orgill

Julian Daich

Luca Lancerotto

A system and method for promoting angiogenesis and adipogenesis in soft tissue using a tissue enlargement apparatus. The tissue enlargement apparatus includes an interface configured for affixation to the soft tissue. A force generating device is coupled to the interface by a connecting tube for applying mechanical forces to the soft tissue. A processor is coupled to the force generating device and is configured to apply intermittent cyclical patterns of the mechanical forces to the soft tissue to promote angiogenesis and adipogenesis in soft tissue. The intermittent cyclical patterns are based on at least one of duration, frequency, and intensity of the mechanical forces.

Systems and methods for promotion of angiogenesis and adipogenesis in tissues through application of mechanical forces

A negative pressure wound treatment system comprising a bandage portion and a negative pressure portion. The bandage portion includes a dressing portion in contact with a wound and a sealing layer positioned in contact with the dressing portion. The sealing layer includes an adhesive creating a seal around the wound. The negative pressure portion is in fluid communication with the bandage portion and includes a first valve and a second valve. The first valve is in fluid communication with the bandage portion and the negative pressure portion. The second valve is in fluid communication with the negative pressure portion and the surrounding environment. The negative pressure wound treatment system is configured to provide negative pressure to an area sealed by the bandage portion upon the actuation of the negative pressure portion. The negative pressure portion is configured to be actuated by compressing the negative pressure portion while walking.

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Brookline, MA, United States of America

Giorgio Giatsidis