Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Giorgio Fedrizzi

Patrizia Ferrari

Mauro Gobbini

Giuseppe Bianchi

Alberto Cerri

Marco Torri

Walter Cabri

Piero Melloni

Marco Santagostino

Rosamaria Micheletti

Sergio De Munari

Giuseppe Marazzi

Alessandra Benicchio

Marco Pozzi

Piero Enrico Scotti

New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application. 

Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms. 

Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##

Seco-d steroids active on the cardiovascular system, processes for their

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Treviglio, Italy

Giorgio Fedrizzi