Iridex Corporation

National University Hospital (singapore) Pte. Ltd.

National University of Singapore

Aleyegn Technologies LLC

Giorgio Dorin

David M Buzawa

Paul T K Chew

Satish Herekar

John Randall Samples

Benedetto Falsini

Paolo Lanzetta

Michael K Ballard

William Eddington

Perry Binder

Systems, devices, and methods for treating a glaucomatous eye are provided. An amount of pulsed laser energy is delivered to the pars plana of the eye by a hand-holdable device which comprises a hand-holdable elongate member and a contact member disposed on an end of the elongate member. A contact surface of the contact member is placed in direct contact with the eye so that a reference edge of the contact member aligns with the limbus and a treatment axis defined by the elongate member is angularly offset from the optical axis of the eye. The amount of pulsed laser energy delivered is insufficient to effect therapeutic photocoagulation but is sufficient to increase uveoscleral outflow so as to maintain a reduction from pre-laser treatment intraocular pressure. Amounts of pulsed laser energy will be transmitted to a circumferential series of tissue regions of the eye.

Contact probe for the delivery of laser energy

An ab externo automated laser treatment system for treating an eye in a subject, includes a non-contact laser source configured to generate a laser beam having at least one wavelength to treat the eye by directing the laser beam from a location spaced from the eye, wherein the at least one wavelength is a near-infrared wavelength in the range of about 0.5-2.2 &#x3bc;m, a laser scanner optically coupled to the non-contact laser source to receive the laser beam from the non-contact laser source and to scan the laser beam relative to the eye, and a processor, and memory including stored computer-readable instructions that, responsive to execution by the processor, cause the laser treatment system to direct the laser beam to a plurality of trans-scleral treatment locations to be irradiated in a predetermined treatment pattern on an external surface of the eye, wherein the trans-scleral treatment locations are 0-4 mm posterior to the corneolimbal junction, and wherein the laser beam is repetitively directed to the same irradiated trans-scleral treatment locations on the surface of the eye, and the trans-scleral treatment locations are irradiated at intervals sufficient to induce protective thermal preconditioning and therapeutic bio-stimulation of one or more of the trabecular meshwork and/or ciliary body without photocoagulation of the tissue of the eye. Trans-pupillary systems, patient interfaces, and methods are also disclosed.

Laser therapy for treatment and prevention of eye diseases

A method of monitoring and controlling the sub-threshold laser treatment of a patient's retina. Sensors are located on a patient to measure focal electroretinograms (FERG). A stimulating beam is delivered onto the patient's retina. A pre-treatment FERG signal is collected. Treatment FERG signals are collected while treating the retina with a sub-threshold laser treatment. A difference is determined between the pre-treatment and treatment FERG signals. The difference is used to control the termination of the treatment.

Method and apparatus for controlling sub-clinical laser procedures with intra-operative monitoring of electrophysiological changes

An optical system is provided for use with a target site and includes a laser source producing an output beam and a reflector. A beam splitter is positioned to receive the output beam and splits the output beam into a first beam incident on the reflector and a second beam incident on at least one point of the target site. The reflector is adjustably positioned and movable along the reference optical path moveable along the reference optical path to change a length of the reference optical path.

Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation

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Cupertino, CA, United States of America

Giorgio Dorin