Other

Smithkline Beecham Corporation

Glaxosmithkline LLC

Chemi S.p.a.

Boehringer Biochemia Robin S.p.a.

Riace Establishment

Neuroscienze S.c.a.r.l.

Giorgio Cignarella

Silvano Ronzoni

Mario Grugni

Daniela Barlocco

Imre Moravcsik

Carmelo A Gandolfi

Sergio Tognella

Antal Simay

Paola Vianello

Lorenzo De Ferra

Pietro Massardo

Odoardo Tofanetti

Oreste Piccolo

Giuseppe Giardina

Gyula Papp

Giuseppe Arnaldo Maria Giardina

P&aacute;l Berzsenyi

P&eacute;ter M&aacute;tyus

Alice Druga

Tivadar Rettegi

Ildik&oacute; Varga

Andr&aacute;s Varr&oacute;

Daniella Barlocco

M&aacute;rta P&aacute;tfalusi

Piervitto Cipolla

Compounds of formula (I) or a derivative thereof, wherein; R is Calkyl, Ccycloalkyl, Calkoxy, hydroxy, halo, Calkenyl, Calkynyl, amino, Calkylamino, di(Calkyl)amino, hydroxyCalkyl, CalkoxyCalkyl, aminoCalkyl, (Calkyl)aminoCalkyl, di(Calkyl)aminoCalkyl; Ris hydrogen or R; Ris hydroxy, Calkoxy, amino, Calkylamino, di(Calkyl)amino; Ris hydrogen or Calkyl; Rand Rare each independently selected from the list consisting of perhaloCalkyl, hydrogen, halo, Calkyl, Calkoxy, hydroxy, amino, Calkylamino, di(Calkyl)amino, hydroxyCalkyl, CalkoxyCalkyl, aminoCalkyl, (Calkyl)aminoCalkyl, di(Calkyl)aminoCalkyl, aryl, and COX wherein X may be hydroxy, Calkoxy, Calkyl, amino, Calkylamino, or di(Calkyl)amino; with the proviso that, when Ris hydrogen, then Rand Rare not both hydrogen; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more times by halo; are ligands of the ORL-1 receptor and are useful in therapy. 

Benzosuberonylpiperdine compounds as analgesics

Compounds of formula I, or a salt thereof or a hydrate thereof, as follows:wherein

Compounds

Process for the preparation of 3-substituted 4-phenyl-piperidine derivative

The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1)

Antiarrhythmic compounds

9,10-diazatricyclo[4,4,1,1.sup.2,5 ] decane and 2,7-diazatricyclo

3-8-diazabicyclo �3.2.1! octane derivatives having analgesic activity

The tricyclic dihydropyridazinone derivatives having formula I ##STR1## are endowed with interesting hypotensive, vasodilating, antiaggregant, antithrombotic and cytoprotective properties and are therefore useful in human or veterinary medicine.

Tricyclic dihydropyridazinones and pharmaceutical compositions

Growing community of inventors

Milan, Italy

Giorgio Cignarella