Biochem Pharma Inc.

Gemin X Pharmaceuticals Canada Inc.

Cytovia, Inc.

Shire Biochem, Inc.

UniversitÈ Laval

Gemin X Biotechnologies Inc.

Gemin X Pharmaceuticals Canada Inc./gemin X Pharmaceutiques Canada Inc.

Giorgio Attardo

Marc Courchesne

Rabindra Rej

Sasmita Tripathy

Serge Lamothe

Yves St-Denis

Jean-Francois Lavallee

Sui Xiong Cai

Boulos Zacharie

Elise Rioux

Denis Labrecque

Wuyi Wang

Dieu Nguyen

Yao-Chang Xu

France Barbeau

Elaine Lebeau

Terrence W Doyle

Songchun Jiang

Guy Falardeau

Richard Storer

Roy A Johnson

Martin Gagnon

Jean-Francedillaois Lavall Ee

Tibor Breining

Jean Louis Kraus

Laval Chan

Hong Zhang

Lyne Gagnon

Christopher L Penney

Samuel C Fortin

James B McAlpine

Monica Bubenik

Shaun Abbott

Bernard Belleau, Deceased

Real Denis

William E Kemnitzer

Angela M Stafford

Xavier Billot

Réal Denis

Pierre Beauparlant

Jean-Louis Kraus

R&eacute;al Denis

Timothy P Connolly

Salam Kadhim

Sasmita Triparthy

Jean-Francedillaois Lavallee

Gerson Gonzalez

Serge Lamonthe

Elisc Rioux

Terrance W Deyle

Zhiying Zhang

Rosa Ubillas

Karen Meerovitch

Lifen Xu

Sylvie Charron

Patrice Pr&eacute;ville

Kenza Dairi

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

Pyrimidines as novel therapeutic agents

The present invention relates to novel Dipyrrole Compounds, compositions comprising a Dipyrrole Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Dipyrrole Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. The invention also provides screening assays for compounds that can be used in combination with Dipyrrole Compounds for the treatment of cancer or neoplastic disease, inhibition of cancer cell growth, or treatment of viral infections.

Dipyrrole compounds, compositions, and methods for treating cancer or viral diseases

The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.

Triheterocyclic compounds and compositions thereof

Methods for treating cancer

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R, R-R, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

Pyrrole-Type compounds, compositions and methods for treating cancer or viral disease

The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof

Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases

The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents

The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for causing immunosuppression. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing an autoimmune disease.

Pyrrole-type compounds, compositions, and methods for treating cancer, treating viral diseases and causing immunosuppression

A novel compound which inhibits certain integrins, particularly &#x3b1;integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.

Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer

The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:or pharmaceutically acceptable salts or prodrugs thereof, wherein:wherein A, R, R, R, X, Y, and Z, are defined herein and B is a fused thiazole, oxazole, 2-imino-imidazole, 2,1,3-thiadiazo-2-one, thiazol-2-one, oxazol-2-one, imidazol-2-thione, thiazol-2-thione, oxazol-2-thione, imidazoline, oxazoline, thiazoline, triazole, oxazine, oxazine-2,3-dione, or piperazine ring. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed towards novel compounds that are effective inhibitors of integrins, particularly &agr; &bgr; or &agr; integrins such as &agr; &bgr; and &agr; &bgr; . One embodiment of the present invention comprises a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt, solvate, or metabolic precursor thereof. R1, R2, R3, and R4 are defined herein.

Quinolizinones as integrin inhibitors

The present invention comprises compounds that are effective inhibitors of integrins, particularly &agr;v&bgr;3 and &agr;v&bgr;5 integrins. Particularly, the compounds are of formula I

Thiophene integrin inhibitors

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Laval, Canada

Giorgio Attardo