Università Degli Studi Di Ferrara

Associazione Veneta Per La Lotta Alla Talassemia

Associazione Per La Lotta Alla Talassemia Di Ferrara

Chiesi Farmaceutici S.p.a.

Giordana Feriotto

Roberto Gambari

Nicoletta Bianchi

Carlo Mischiati

Pier Giovanni Baraldi

Romeo Romagnoli

The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a medicament for the therapeutic treatment of &#x3b2;-thalassaemia.

Heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of &#x3b2;-thalassaemia

The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human &#x3b3;-globin gene; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the &#x3b3;-globin gene and the &#x3b4;&#x3b2;-cluster, for use as an inducer of erythroid differentiation.

Synthetic oligonucleotides as inducers of erythroid differentiation

Growing community of inventors

Occhiobello, Italy

Giordana Feriotto