Chiesi Farmaceutici S.p.a.

Gino Villetti

Bruno Pietro Imbimbo

Andrea Rizzi

Ilaria Peretto

Luca Raveglia

Stefano Radaelli

Elisabetta Armani

Gabriele Amari

Renato De Fanti

Paolo Chiesi

Carmelida Capaldi

Paolo Ventura

Laura Carzaniga

Juan Lorenzo Catena Ruiz

Maurizio Del Canale

Simone Ottonello

Isabel Masip Masip

Oriana Esposito

Claudio Pietra

Riccardo Patacchini

Valentina Cenacchi

Nadia Moretto

Rodolfo Berni

Dalila Mango

Elisa Landucci

Fabrizio Facchinetti

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors

Derivatives of 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid are capable of stabilizing the tetrameric native state of transthyretin for the prophylaxis and treatment of amyloidosis.

1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis

1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.

1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

The invention provides inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are new ester derivatives, methods of preparing such compounds, compositions containing them, and therapeutic uses thereof.

Ester derivatives as phosphodiesterase inhibitors

Quinuclidine derivative of the general formula (I) in the form of single enantiomers or mixtures thereof are useful in the manufacture of a medicament for the prevention and therapy of respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cough and emphysema wherein:

Quinuclidine derivatives as M3 antagonists

The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.

Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases

The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of A&#x3b2;42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Yrx). Polypeptides bearing multiple copies of A&#x3b2;42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers A&#x3b2; within neuritic AD plaques.

Anti-amyloid immunogenic compositions, methods and uses

.alpha.-amino acid amides, preparation thereof and the therapeutical use

Growing community of inventors

Parma, Italy

Gino Villetti