Nereus Pharmaceuticals, Inc.

Celgene International Ii Sarl

Triphase Research and Development I Corp.

Ginger Tsueng

Kin S Lam

Barbara Christine Potts

Jennifer Grodberg

Scott Sherman Mitchell

Katherine Anne Reed

Donald J White

Michael A Palladino

Scott S Mitchell

Barbara C Potts

Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin Bat specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.

Salt formulations for the fermentation of marine microorganisms

Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.

Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Bis-indole pyrroles useful as antimicrobials agents

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San Diego, CA, United States of America

Ginger Tsueng