The Procter Gamble Company

Gina Marie Fadayel

Kenneth Robert Wehmeyer

Dean Larry DuVal

James Robert Schwartz

Raphael Warren

Rohan Lalith Wimalasena

Charles Carson Bascom

Miranda Aref Farage

David Burton Moore

Kathleen Marie Kerr

Angela Marie Fieno

Jay Patrick Tiesman

Murray A Friedman

Patricia West Doyle

Thomas Massey Burt

An array of methods for assessing vaginal atrophy are disclosed. The methods may be used alone or in combination with a treatment or as part of a kit.

Methods for assessing vaginal atrophy

A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.

Noninvasive method for measuring histamine from skin as an objective measurement of itch

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Maineville, OH, United States of America

Gina Marie Fadayel