Duphar International Research Bv

Gillis P Van Der Wal

Jan W Mijers

An automatic injector for the separate storage of a solid and a solvent for this solid. The injector comprises a discharge mechanism, a cartridge assembly and a front cover which is connected to a front portion of the cartridge assembly and provided at its front with a pierceable central area. The cartridge assembly comprises a hollow barrel, a pierceable stopper connected to the front portion of the barrel and constituting a compartment in front of said stopper for accommodating the solid, a piston slidably accommodated in the backward portion of the barrel and constituting a compartment for liquid in the barrel, an injection needle longitudinally extending in the liquid compartment, and means for centering the distal end of the needle in order to position the needle tip towards the pierceable stopper. The front cover is capable of rotational movement relative to the outer sleeve to allow the liquid in the barrel to reach the solid compartment through the needle. The injection needle is accommodated in the barrel in an unfixed manner to allow relative longitudinal movement between the injection needle and the barrel.

Automatic injector

The present invention relates to an injection device for the automatic injection of at least one injection liquid, comprising an assembly of a discharge mechanism, a cartridge holder and a cartridge slidably accommodated in the cartridge holder, the discharge mechanism comprising an outer sleeve wherein the cartridge holder is slidably adapted. A protective cover is provided on the front of the device, covering the front portions of the cartridge holder and the outer sleeve in such a manner, that unintentional backward movement of the cartridge holder in the outer sleeve, resulting in activation of the device, is prevented.

Injection device

The invention relates to a training device for an automatic injector. The device comprises a cylindrical outer sleeve in the rear portion of which a discharge mechanism is connected and in the front portion of which a holder intended for accommodating a punch member is incorporated so as to be locked against forward movement. The discharge mechanism comprises a plunger, a coil spring which acts on the plunger, a locking device and a safety member. The holder for the punch member comprises a sleeve-like rear portion which is open at each end. The punch member is accommodated in the holder such that its rear end at least substantially engages the front end of the plunger, and such that the front prod-shaped end portion which has dimensions such that it can pass through the central aperture in the nose portion of the holder outwards, is present within the holder prior to use of the device. The device further comprises auxiliary means for making the device ready for reuse. The rear end portion of the punch member comprises means which, in cooperation with means provided on the inner wall of the sleeve-like rear portion of the holder, prevent undesired forward movement of the punch member in the holder, in which, however, the device at the area of the means is proportioned such that, after activation, the wall of the holder can expand resiliently outwards within the outer sleeve to allow the punch member to pass.

Training device for an automatic injector

The invention relates to an automatic injector for injecting one or more injection liquids, comprising an assembly of a discharge mechanism, a cartridge in a cartridge holder, and an outer sleeve which is telescopically slidable around the cartridge holder, which cartridge comprises a barrel, in the barrel a piston and a number of separating stoppers equal to one less than the number of injection liquids, a needle holder with injection needle and optionally a by-pass for injection liquid. The injector is suitable for accommodating a solid and a solvent therefor, and for that purpose comprises a passable stopper between solid and solvent and a solvent by-pass in the barrel wall or in the passable stopper, in which, by a single or repeated operation of telescoping external parts of the injector solvent can pass the passable stopper and can reach the solid, as a result of which the injector can be made ready for use.

The invention relates to an automatic injection device comprising an assembly of a discharge mechanism, a cartridge holder of synthetic material and a cartridge which is slidably accommodated in the cartridge holder. The cartridge includes a glass ampoule, if desired, enveloped by a sheath of shrinkable sheet, the ampoule consisting of an ampoule cylinder in which an injection liquid or various injection liquids separated from each other by stoppers and a piston which can be moved in the ampoule cylinder are provided. The assembly also includes a connection means for an injection needle in which or to which the injection needle, if desired, covered by a guard to maintain the needle in a sterile condition, is connected, and a shoulder between the ampoule cylinder and the needle connection means. The cartridge holder consists of a sleeve-like rear portion which is open at each end and which, after actuating the injection device, is traversed by the ampoule cylinder and the inner surface of which has substantially the same transverse dimensions over the whole length, and a front portion which forms one assembly with the sleeve-like portion and, after actuating the syringe, serves to discontinue the forward movement of the cartridge in the holder and to allow passage of the needle. The sleeve-like portion of the cartridge holder has a five-sided to fourteen-sided cross-section over a length which is at least equal to the length of the ampoule cylinder and is proportioned such that the ampoule cylinder engages the inner side surfaces of the sleeve-like portion with friction. The invention furthermore relates to a cartridge holder for the injection device.

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Olst, Netherlands

Gillis P Van Der Wal