The Procter Gamble Company

Procter & Gamble Pharmaceuticals, Inc.

Gilles Yves Genain

Song Liu

David Edward Portlock

Jean-Jacques Koenig

Jacques De Rostolan

Chia-Nien Yu

Randy Stuart Muth

Rachel Boujo

Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

Urethane-containing aminosteroid compounds

The present invention relates to a method for making a compound of the structure: ##STR1## comprising the steps: (a) adding 6-deoxy-.alpha.-L-mannopyranosyl bromide, 2,3,4-tri-O-benzoate; DMSO; a base, selected from the group including tertiary amines, amidines, bicarbonates, carbonates, heteroaryl amine, and a solvent, hydrocarbons, esters, and ethers, in a slurry heated to 50.degree.-150.degree. C.;

Deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds

Disclosed are 14-aminosteroid compounds, including pharmaceutically acceptable acid salts and esters thereof, useful in treating individuals afflicted with congestive heart failure, which compounds have the general formula: ##STR1## wherein R.sub.3 is a deoxy or oxygen-substituted monosaccharide sugar residue and R.sub.1, R.sub.2 and R.sub.4 are various other substituents as defined herein.

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Wyoming, OH, United States of America

Gilles Yves Genain