Sanofi

Gilles V Courtemanche

Camille G Wermuth

Pierre M Roger

Michel Jacques Geslin

Claudie Suzanne Gautier

Simon F Campbell

Alain Pellet

Daniele Anne Gully

Cécile Pascal

Daniel A Gully

The present disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein Rmeans a fluorine atom or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms; Rmeans a chlorine atom, a linear alkyl radical containing 1, 2 or 3 carbon atoms or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms, and R means a hydrogen atom or a radical of formula (Ia). The present disclosure also relates to processes for their preparation as well their therapeutic uses, in particular such as for use in the treatment of malaria.

Ethynyl compounds, their preparation and their therapeutic use for the treatment of malaria

The invention concerns compounds of the formula I: ##STR1## in which R.sub.1 to R.sub.5 are as defined in claim 1. These compounds find their application in the treatment of pathologies involving CRF.

Branched-amino-substituted thiazoles, processes for their preparation

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St. Martin du Tertre, France

Gilles V Courtemanche