Galderma Research & Development

Gilles Ouvry

Etienne Thoreau

Claire Bouix-Peter

Branislav Musicki

Yushma Bhurruth-Alcor

Laurence Clary

Jean-François Fournier

Loïc Tomas

Craig Steven Harris

Maryline Bourotte

Benoît Deprez

The invention relates to novel mTOR inhibitor compounds having the formula (I) or a pharmaceutically acceptable salt thereof, compositions comprising the mTOR inhibitor compounds, methods for producing the same, and the use thereof.

Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors

The invention relates to novel mTOR inhibitor compounds having the general formula (I), to compositions comprising said mTOR inhibitor compounds, methods for producing same, and the use thereof in compositions as a drug. 

MTOR inhibitor compounds

Indazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma ROR&#x3b3;t are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR&#x3b3;t receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Indazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T))

Benzimidazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma ROR&#x3b3;t are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR&#x3b3;t receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Benzimidazole sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (T))

Compounds having formula (I) are described.  Also described, are methods of using these compounds to treat diseases, conditions, and disorders.

Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics

Tetrahydroquinoline sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (ROR&#x3b3;t) are described. Pharmaceutical compositions including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR&#x3b3;t receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Tetrahydroquinoline sulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (ROR gamma (t))

Benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonist of retinoid-related orphan receptor gamma (ROR&#x3b3;t) are described. A pharmaceutical composition including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR&#x3b3;t receptor-medicated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Growing community of inventors

Biot, France

Gilles Ouvry