Bracco Suisse Sa

Csl Behring Ag

Centre Hospitalier Universitaire Vaudois

Gilles Bioley

Philippe Bussat

Anne Lassus

Blaise Corthesy

Michel Schneider

Cédric Pierre Vonarburg

Blaise Corthésy

The invention relates to methods promoting the aggregation ofbacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection.

Methods for affectinginfections

Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.

Gas-filled microvesicles for use as vaccine

Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.

Methods of using gas-filled microvesicles covalently bound to an antigen

Growing community of inventors

Fiez, Switzerland

Gilles Bioley