Institut National De La Sante Et De La Recherche Medicale

Université De Nantes

National University of Ireland, Galway

National University of Ireland

Institut Francais De Recherche Pour L'exploitation De La Mer (ifremer)

Chu Nantes

National University of Ireland, Galway (nuig)

Gildas Rethore

Abhay Pandit

Hemantkumar Naik

Yvonne Lang

David Finn

Pierre Weiss

Emile Rederstorff

Samia Laib

Jérome Guicheux

Emilie Rederstorff

The invention concerns: &#x2014;a silylated biomolecule having the following formula (I): &#x2014;the process for the preparation of a silylated biomolecule of formula (I), &#x2014;the use of a silylated biomolecule of formula (I) to functionalize the surface of a support, &#x2014;a process for the preparation of a hydrogel by use of a silylated biomolecule of formula (I), the hydrogel obtainable by said process, &#x2014;said hydrogel as a biological tissue substitute, &#x2014;a composition comprising said hydrogel in a pharmaceutically acceptable vehicle, &#x2014;said composition for the release of active principle. 

Silylated biomolecules

A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterized in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.

Hollow biodegradable nanospheres and nanoshells for delivery of therapeutic and/or imaging molecules

An activatable functionalised Ngeneration dendrimer having: a core comprising a first monomer having at least two carboxylic acid functional groups; and N successive generations, where N=0 to 10, wherein each generation comprises: a second monomer having at least two alcohol functional groups, wherein at least one alcohol group is bonded to a carboxylic acid group of the first monomer of the prior generation, and an additional first monomer attached to a second alcohol function group of said second monomer of that generation; and the final generation having attached thereto at said second alcohol functional group of said second monomer, a moiety having a dicarboxylic acid functional group, activatable by treatment with a carboxylic acid activating reagent such that reactivity of the carboxylic acid functional group is increased. The dendrimer, when activated, may be used in applications such as polymer crosslinking and/or nanoshell production.

Dendrimers and dendrimer applications

A polymeric hollow nanoshell or nanosphere for release of an agent is described, wherein the hollow nanosphere comprises at least one biodegradable polymer, characterised in that the polymer is cross-linked. The biodegradable mono-disperse nanospheres described are suitable for use as carriers of biomolecules, therapeutic agents and/or imaging agents.

Growing community of inventors

Nantes, France

Gildas Rethore