Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Mcgill University

Universita′ Degli Studi Di Milano

Università Degli Studi Di Parma

Universita Degli Studi Di Urbino

Gilberto Spadoni

Giorgio Tarzia

Patrizia Minetti

Marco Mor

Maria Assunta Di Cesare

Franco Fraschini

Gabriella Gobbi

Valeria Lucini

Silvia Rivara

Annalida Bedini

Novel melatonin ligands of Formula I: or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR; Y is selected from the group consisting of hydrogen, aryl, heteroaryl, C-Calkyl, C-Ccycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, &#x2014;OCF, CF, C-Calkyl, C-Calkyloxy, C-Calkylthio, halogen and &#x2014;Z&#x2014;(CH)-A; Ris selected from the group consisting of C-Calkyl, C-Ccycloalkyl, CF, hydroxy-substituted C-Calkyl, hydroxy-substituted C-Ccycloalkyl, and NHR, wherein Ris C-Calkyl or C-Ccycloalkyl; Ris selected from the group consisting of: hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; R and Rmay be connected together to form an &#x2014;O&#x2014;(CH)bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; Ris selected from the group consisting of hydrogen and C-Calkyl; Ris selected from the group consisting of hydrogen, C-Calkyl, C-Calkyloxy, OCF, CF, hydroxyl, and halogen; and Ris selected from the group consisting of hydrogen and C-Calkyl.

Melatonin ligands having antidepressant activity as well as sleep inducing properties

Compounds of Formula (I): (I); wherein: Rand Reither the same or different, are H or linear or branched C&#x2013;Calkyl; R=linear or branched C&#x2013;Calkyl; R=halogen, and pharmaceutically acceptable salts thereof are useful as active ingredients in the preparation of medicaments used as ligands of the 5-HTand/or 5-HTserotoninergic receptors.

[object Object]

Growing community of inventors

Urbino, Italy

Gilberto Spadoni