Biolab Sanus Farmaceutica Ltda

Gilberto De Nucci

Carlos Eduardo Da Costa Touzarim

Sérgio Luiz Sacurai

Artur Franz Keppler

Marcio Henrique Zaim

Márcio Henrique Zaim

Sergio Luiz Sacurai

The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): or pharmaceutically acceptable salts thereof, or their mixtures (in any ratio), a pharmaceutical composition containing them, a method for using the new pyridopyrimidine derivatives compounds as inhibitor of the cyclic nucleotide synthesis or as inhibitor of the cAMP and cGMP synthesis, and their uses in the prophylactic and/or curative treatment of diarrhea, colitis and irritable bowel syndrome.

Pyridopyrimidines derivatives compounds

A series of derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, compounds of formula (I), where R, R, R, and Rare defined herein, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders. 

Derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,9-dione as PDE-5 inhibitors

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São Paulo, Brazil

Gilberto De Nucci