Sanofi

S.a. Labaz N.v.

Labaz

S. A. Labaz-sanofi N.v.

Gilbert Rosseels

Henri Inion

Jean Gubin

Pierre P Chatelain

Jean Lucchetti

Peter Polster

Pierre Nokin

An aminoalkoxyphenyl derivative of general formula:

Aminoalkoxyphenyl derivatives, process for their preparation and

The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T' and T'represent particularly a group: ##STR3## R and R.sub.a, identical or different, represent X represent --O-- or --S--

Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and

Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,

Indolizine derivatives and use as cardiovascular agents

Indolizine derivatives corresponding to the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents a straight- or branched-chain alkyl radical having from 1 to 4 carbon atoms or a phenyl radical, R.sub.1 represents a straight- or branched-chain alkyl radical having from 1 to 6 carbon atoms, X.sub.1 represents hydrogen, chlorine, bromine, methyl or methoxy, A represents a radical of the formula: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, methyl or methoxy, n represents 1 or 2, a process for preparing said derivatives, pharmaceutical or veterinary compositions containing at least one of said derivatives and a method of treating pathological syndromes of the heart by administration of at least one of said derivatives to a subject in need of such treatment.

Indolizine derivatives and their use in treating heart ailments

Indolizine derivatives represented by the general formula: ##STR1## wherein R represents a straight- or branched-chain alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, which may be the same or different, selected from halogen atoms, for example fluorine, chlorine and bromine and from lower alkyl and alkoxy groups, for example methyl and methoxy and X.sub.1, X.sub.2 and X.sub.3, which may be the same or different, each represent hydrogen, chlorine, bromine or methoxy with the proviso that when they are identical X.sub.1, X.sub.2 and X.sub.3 are not simultaneously hydrogen. They possess an inhibitory activity with respect to the action of xanthine oxidase and of adenosine deaminase as well as an uricosuric action and can be used in the treatment of physiological disturbances consequent upon an excess of uric acid, upon disorders of the immunization system and as antiparasitic agents.

Indolizine derivatives and uses in therapeutics

Indolizine derivatives and process for preparing the same

Novel indolizine derivatives of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl radical having from 1 to 5 carbon atoms, a phenyl radical, a mono-fluoro-, mono-chloro- or mono-bromo-phenyl, a di-fluoro-, di-chloro- or di-bromo-phenyl radical, a methoxy-phenyl radical or a methyl-phenyl radical optionally substituted on the aromatic moiety by an atom of fluorine, chlorine or bromine and R.sub.1 and R.sub.2, which are different, represent a hydrogen atom or a group of the formula: ##STR2## wherein R.sub.3 and R.sub.4 which are identical, each represent a hydrogen atom or a methyl radical, Am represents a dimethylamino, diethylamino, di-n-propylamino, di-n-butylamino, morpholino, piperidino, pyrrolidino or 4-methyl-piperazino group and n is an integer in the range of from 2 to 6 inclusive. They are effective for treating certain pathological or otherwise abnormal conditions of the heart and more particularly sinus tachycardia. Certain of them are also useful in the treatment of angina pectoris and cardiac arrhythmia.

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Wemmel, Belgium

Gilbert Rosseels