Cognition Therapeutics, Inc.

Other

Amgen Inc.

Gilbert M Rishton

Susan M Catalano

Gary Charles Look

Steven Paul Tanis

Bradley Teegarden

Robert Alan Chrusciel

Thomas Jay Lobl

Edward V Thomas

Jed F Fisher

Alexander Polinsky

Masafumi Yamagishi

Celia Dominguez

Michael G Kelly

Christopher Harold Fotsch

Guolin Cai

Paul E Harrington

David Joseph St Jean, Jr

Thomas Stephen Coulter

Yuelie Lu

Chiara Ghiron

Philip Miller

Jennifer N Chau

David J Semin

Kristin Beierle

Cody Lee Fullenwider

Zoya Kai

Hiromi Arai

David J St Jean, Jr

Thomas S Coulter

Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

Isoindoline compositions and methods for treating neurodegenerative disease

The present disclosure relates to novel compounds of Formula I wherein each of R, R, Rand Ris independently H; Ris selected from the group consisting of H, hydroxyl, halo, alkyl, alkoxy, CF, SOCH, and morpholino, Ris selected from the group consisting of hydrogen, alkyl, phenyl, or —CH═C(CH); and Ris specific substituted cyclic amino groups. The invention also discloses pharmaceutical compositions containing the compounds and methods of using the compounds and pharmaceutical compositions for treating neurogenerative diseases, including Alzheimer's disease and cognitive decline.

Compositions for treating neurodegenerative diseases

The present disclosure relates to novel compounds, and pharmaceutical compositions thereof, useful for treating for treating neurodegenerative diseases, including Alzheimer's disease and cognitive decline. Methods for inhibiting synapse number decline or membrane trafficking abnormalities associated with exposure of a neuronal cell to Abeta species are also disclosed. Representative members of these compounds include: 

Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.

Inhibitors of cognitive decline

Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.

Isolated compounds from turmeric oil and methods of use

The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I. 

Calcium receptor modulating agents

Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivative of ginger oil are also provided. Also provided is a method of conditioning biological extracts, such as a medicinal plant extract, by a reductive amination process to give nitrogen-containing derivatives.

Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-&#x3b1;, IL-1&#x3b2;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted indolizine-like compounds and methods of use

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Los Angeles, CA, United States of America

Gilbert M Rishton