Imperial Chemical Industries Limited

Gilbert J Stacey

David R Brittain

Edward D Brown

Walter Hepworth

Anand Swaroop Dutta

Christopher F Hayward

John S Morley

James J Gormley

Alan F Hawkins

David P Pearson

Nigel N Petter

This invention relates to a method of inducing tillering in cereal plants using certain 5-phenyl-3-pyridinecarboxylate compounds, to certain of the compounds themselves, to a process for preparing these compounds, and to agricultural compositions containing them. The compounds are also useful as intermediates for preparing other of the compounds.

Method for inducing tillering utilizing certain pyridine-1-oxides

The disclosure relates to novel polypeptides which possess analgesic activity, to processes for their manufacture and to pharmaceutical compositions containing them. Typical of the peptides disclosed is: ##STR1##

Polypeptide

Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.

1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmaceutical

Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic

The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is

Analgesic and sedative polypeptides

Alkanoic acid 2-quinoline derivatives

Growing community of inventors

Macclesfield, United Kingdom

Gilbert J Stacey