Ortho Diagnostic Systems Inc.

Millipore Corporation

Ortho-clinical Diagnostics, Inc

Gilbert J Quinton

Robert W Van Holten

Dennis M Mochnal

Janice Jakway

George E Oulundsen, Jr

Dennis Mochnal

Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of virus and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and with excipient such as polysorbate 80. Additional steps include diafiltration to concentrate the anti-D protein and reduce the concentration of excipient present.

Viral clearance process

A method for preparing treated naturally occurring or synthetic particles using a blood cell processor is provided. The method comprises adjusting the blood cell processor to allow a dispersion of such particles to come into contact with a treatment material in an amount and for a period of time sufficient to modify all or a portion of the surface of such particles. In a preferred embodiment, the method comprises washing collected red blood cells; separating a selected volume of said washed red blood cells; and treating one portion of said separated washed cells with a selected proteolytic enzyme, to prepare a red blood cell reagent.

Automated process for preparing treated microparticles especially blood

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Belle Meade, NJ, United States of America

Gilbert J Quinton