Greenovation Biotech Gmbh

Phyton Holdings, LLC

Alvi, Khisal

Srinivasan, Venkatesh

Gorr, Gilbert

Alford, Jennifer

Horn, Michael

Slusar-Place, Beth

Swindell, Charles

Gilbert Gorr

Wolfgang Jost

Manfred Schuster

Harald Heckenmüller

Ralf Kircheis

Marta Rodriguez-Franco

Andreas Weise

David Alexander Ullisch

Christian Stemmer

Yantree Devi Sankar-Thomas

Andreas Nechansky

Charles S Swindell

Ralf Reski

Venkatesh Srinivasan

Khisal Alvi

Eva Decker

Michael Horn

Thomas Selge

Thomas Leibold

Otmar Lienhart

Anna Koprivova

Heike Launhardt

Marta Rodriguez Franco

Harald Heckenmuller

Jennifer Alford

Jens Stefan Wilke

Beth Slusar-Place

Stefan Rensing

Birgit Berg

Charles Swindell

The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genusin a nutrient medium in a suspension cell culture, wherein the cells produce one or more sesquiterpene lactones of the thapsigargin family; and (b) recovering one or more sesquiterpene lactones of the thapsigargin family produced in (a). The present invention further relates to a suspension cell culture comprising plant cells of the genuswherein the plant cells are capable of producing one or more sesquiterpene lactones of the thapsigargin family and to a plant cell biomass comprising plant cells of the genusobtained from said suspension cell culture.

Production of thapsigargins bycell suspension culture

The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.

Glyco-engineered antibodies

The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures

The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that &#x2022; the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and &#x2022; at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.

The present invention relates to the production of alkaloids from Liliaceae cell culture.

Production of alkaloids by liliaceae cell culture

A method of amplifying gene expression in a moss plant cell or moss tissue, DNA constructs therefor, moss plant cells and uses thereof for the production of protein.

Utilisation of constructs comprising recombination sequence motifs for enhancing gene expression in moss

Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.

Moss expressing promotion regions

Bryophyte plants and bryophyte plant cells comprising dysfunctional fucT and xylT genes and an introduced glycosyltransferase gene, methods for the production of glycosylated proteins therewith, vectors and uses thereof.

Transformed bryophyte cell having disrupted endogenous alpha 1,3-fucosyl and beta 1,2-xylosyl transferase encoding nucleotide sequences for the production of heterologous glycosylated proteins

The present invention relates to a method for producing heterologous glycosylated proteins in non-animal eukaryotic cells such as in transformed bryophyte, yeast, ciliate or algae cells. In particular, the method relates to a method for producing glycosylated proteins comprising animal glycosylation patterns&#x2014;comprising sialic acid residues&#x2014;, such as pharmaceutical proteins for use in mammals, e.g. humans, in bryophyte cells such as those of, the genetic material required therefore, such as DNA and RNA, vectors, host cells, methods of introducing genetic material there into, and uses thereof. Furthermore, the present invention relates to novel polypeptides and proteins obtained by the method according to the invention. Moreover, the present invention provides a method of producing sialic acid or CMP-sialic acid in a transformed non-mammalian eukaryotic cell, tissue or organism.

Transformed plant cell expressing five mammalian proteins involved in sialylation and a protein involved in galactosylation

Moss expressing promoting regions

Growing community of inventors

Freiburg, Germany

Gilbert Gorr