Raindance Technologies, Inc.

Bio-rad Laboratories, Inc.

Jds Uniphase Corporation

Gilbert Feke

Jonathan Marc Rothberg

Wolfgang Hinz

Darren Roy Link

Michael Weiner

David Marran

John Q Lu

Ahmadali Tabatabai

Laurent Boitard

Jeffrey Branciforte

Yves Charles

Karl M Kissa

Jonathan M Rothberg

Hirotoshi Nagata

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

Microfluidic devices and methods of use in the formation and control of nanoreactors

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

An optical modulator which has substantially low loss and has an improvement in voltage reduction is disclosed having an electro-optic lithium niobate substrate. The substrate has first, second and third ridges extending along its surface. Extending along the first and second ridges are first and second waveguides. A first RF electrode extends over the first waveguide and a second slotted electrode including a first section extends over the second waveguide. A second section of the slotted extends parallel to and adjacent to the first section on the third ridge. In summary, this invention provides a slotted ground electrode wherein a slot is formed in the substrate between the slotted electrode.

Controllable electro-optic device having substrate trenches between electrodes

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West Simsbury, CT, United States of America

Gilbert Feke