Carestream Health, Inc.

Bruker Biospin Gmbh

Gilbert Feke

Shoupu Chen

Douglas Lincoln Vizard

William E McLaughlin

Laurie L Voci

Warren Matthew Leevy

Rao Papineni

Douglas O Wood

Mark E Bridges

Benjamin F Geldhof

Douglas Wood

Apparatus and method for performing depth sectioned fluorescence imaging of a turbid sample including a fluorescent turbid medium, uses an apparatus for quantitative modulated fluorescence imaging, the apparatus including projection optics with a first optical axis, to expose the turbid sample to a periodic pattern of excitation radiation to provide depth-resolved discrimination of fluorescent structures within the turbid medium; an image capture module, including a second optical axis and a detection beam path, to receive a data image from the sample; and a signal processor to transform the data image from the sample, spatially filter the transformed data image from the sample, and reconstruct the filtered, transformed data image from the sample.

Apparatus and method for fluorescence imaging and tomography using spatially structured illumination

A frame-sequential multiwavelength imaging system comprises a wavelength switching device for producing a repeated series of different wavelength profiles, a detector for detecting the dynamic scene and a signal processing unit for synthesizing a dynamic multiwavelength image of the dynamic scene. The signal processing unit may comprise at least one input device at least one logic device and at least one output device. The system can be used in a method to perform multiwavelength imaging of a dynamic scene, typically for surgical purposes.

Frame-sequential multiwavelength imaging system and method

An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.

Apparatus and method for multi-modal imaging

A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.

Torsional support apparatus and method for craniocaudal rotation of animals

An imaging system for imaging an object. More specifically, an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source wherein the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected to minimize excitation radiation from reaching the detection beam path.

An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system.

Imaging target for testing quality of multiple-magnification focus and image co-registration

A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.

Apparatus and method for imaging ionizing radiation

A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.

Variable condenser for delivery of illumination including recursively nested circle to-line fiber optic converter cable

An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.

An imaging target, suited for use in multi-modal imaging systems, includes test patterns for testing quality of both focus and co-registration for multiple magnifications and multiple modalities of operation of a multimodal imaging system.

A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.

Method and apparatus for multi-modal imaging

An apparatus and method for depth selected fluorescence measurements is provided. The apparatus may include a carrier for at least one sample substance; projection optics; an image capture module; a signal processor to transform the data image to provide depth selected fluorescence measurement for the at least one sample substance. The apparatus is arranged such that a first optical axis is inclined relative to a second optical axis so that the projection optics have an angle of inclination relative to the image plane. The angle of inclination is selected so that a component of excitation radiation incident upon, but not absorbed by, the at least one sample substance is scattered or reflected to reduce excitation radiation from reaching the detection beam path.

Apparatus and method for fluorescence measurements using spatially structured illumination

A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.

Method and apparatus for measuring long bone density of small-animals

A fluorescence reference plate for a fluorescence spectroscopic instrument is arranged with fluorescent layers having different excitation and emission characteristics. The fluorescent layers are ordered in the form of a stack for providing a flat-field calibration standard over multiple bands of wavelengths.

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Durham, CT, United States of America

Gilbert Feke