Elan Corporation, Plc

Gilbert Corneille

Donald E Panoz

Specifically, the present invention relates to processes for preparing delayed action galenic forms. The process is characterized in that the application solutions of excipients, coatings and active constituents are adjusted to a desired pH. The independence of the rate of dissolution of a controlled release or sustained action oral pharmaceutical form is increased by admixing a pH adjusting agent with every application solution of medicament, excipeint or coating, throughout the course of formulation of the pharmaceutical form.

Processes for the preparation of delayed action and programmed release

The present invention relates to a new pharmaceutical form for oral use, in the nature of delayed action and controlled absorption medicaments. The form of the present invention comprises an association of miniaturized granules obtained by high to very high compression: (a) with Ph control agents, (b) coated with excipients determining the slow penetration of digestive liquids, and/or (c) coated with a very thin layer of lipids. These miniaturized granules may contain glucose, may have pH control agents with different solubilities, and may be in the form of miniaturized granules with a pH gradient.

New pharmaceutical forms for administration of medicaments by oral

The present invention relates to a new pharmaceutical form for oral use in the nature of delayed action and controlled absorption medicaments. This form comprises an association of miniaturized granules obtained by high to very high compression: (a) with pH control agents, (b) coated with excipients determining the slow penetration of digestive and/or (c) coated with a very thin layer of lipids. These miniaturized granules may contain glucose, nay have pH control agents with different solubilities, and may be in the form of miniaturized granules with a pH gradient.

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Paris, France

Gilbert Corneille