Ultima Genomics, Inc.

Sunpower Corporation

Applied Materials, Inc.

Applied Materials Israel Limited

Maxeon Solar Pte. Ltd.

Cogenra Solar, Inc.

Ict Integrated Circuit Testing Gesellschaft Fur Halbleiterpruftechnik Mbh

Applied Materials Isreal Ltd

Flurensics Inc.

Gilad Almogy

Nathan Beckett

Ratson Morad

Itai Suez

Jean Hummel

Mark Pratt

John Gannon

Steven Menchen

Dan Maydan

Yafu Lin

Florian Oberstrass

Avishai Bartov

Kristopher Barbee

Tamir Lance

Denis Pristinski

Dumitru Brinza

Linda G Lee

Ron Naftali

Jamie Michael Sullivan

Ehud Tirosh

Meir Aloni

Robert Stuart

Nathan Caswell

Jacob A Wolf

Haim Feldman

Silviu Reinhorn

Phillip You Fai Lee

Doron Meshulach

Theo Nikiforov

Christopher Dennis Bencher

Benyamin Buller

Jürgen Frosien

Abizar Lakdawalla

Derek Schulte

Joseph Anthony

Michael J Starkey

Jose Martin Sosa

Stephanie Kubecka

Boris Goldberg

Yoav Etzioni

Gene Polovy

Omer Barad

Alon Litman

David B DeGraaff

Efrat Rozenman

Evgeni Levin

Chandan Shee

Jimmy Vishnipolsky

Mula Friedman

Amir Weiss

Eliane Trepagnier

Pavel Adamec

Avishay Guetta

Jian Ding

Boaz Kenan

Melvin Warren Montgomery

Wendy H Yeh

Daniel I Some

Doron Shoham

Bryan Conrad Bolt

Oren Reches

Yonatan Lehman

Yung-Hee Yvette Lee

Amir Komem

Alexander Buxbaum

Michael Lawrence Corliss

Oded Arnon

Amir Bar

Ofer Ricklis

Andrey Bochkariov

Osip Schwartz

Simchon Faigler

Phillip Lee

Radu Constantin Raduta

Brian Edward Atchley

Juergen Frosien

Adam Thomas Clavelle

Dror Shemesh

Boris Golberg

Ariel Ben-Porath

Helmut Banzhof

Vicky Svidenko

Youval Nehmadi

Mark Geshel

Chris Talbot

Maritza Ruiz

Jason C Kalus

Ofer Bokobza

Lior Levin

Erez Ravid

Rinat Shishi

Yonatah Lehman

Hadar Mazaki

Zvi Howard Phillip

Silviu Reinhron

Amir Komeem

Yuto Watanabe

Jacob J Orbon, Jr

Joseph Isaac Lichy

Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

Methods and systems for analyte detection and analysis

Methods for detecting a short genetic variant in a test sample are described herein. In some exemplary methods, the short genetic variant is called using one or match scores, which are determined using one or more sequencing data sets obtained from a test nucleic acid molecule, wherein the test sequencing data sets are determined by sequencing the test nucleic acid molecule using non-terminating nucleotides provided in separate nucleotide flows according to a flow-cycle order. Also described herein are methods of sequencing a test nucleic acid molecule using two or more different flow-cycle orders and/or extended flow cycle orders having five or more nucleotide flows per flow cycle.

Methods for detecting nucleic acid variants

The present disclosure provides methods and processes for increasing the efficiency and accuracy of nucleic acid sequencing using techniques such as polymerase chain reaction (PCR). Methods and systems provided herein may facilitate performing reactions such as emulsion PCR (ePCR) on samples comprising nucleic acids and beads. The methods provided herein may provide a higher throughput compared to existing technologies.

Methods and systems for nucleic acid analysis

The present disclosure provides labeling reagents for labeling substrates such as nucleotides, proteins, antibodies, lipids, and cells. The labeling reagents provided herein may comprise fluorescent labels and semi-rigid linkers. Methods for nucleic acid sequencing using materials comprising such labeling reagents are also provided here.

Linkers and methods for optical detection and sequencing

The present disclosure provides methods and processes for increasing the efficiency and accuracy of nucleic acid sequencing using techniques such as polymerase chain reaction (PCR). The methods described herein can be used to achieve clonal amplification even with a greater than Poisson distribution of beads and/or nucleic acid templates into an emulsion. A PCR method may comprise generating a partition (e.g., a droplet) comprising at least two beads and/or at least two nucleic acid molecules and generating clonal amplification products corresponding to the nucleic acid molecule, at least a subset of which may be attached to a bead.

Methods for nucleic acid analysis

A high efficiency configuration for a solar cell module comprises solar cells arranged in an overlapping shingled manner and conductively bonded to each other in their overlapping regions to form super cells, which may be arranged to efficiently use the area of the solar module.

Solar panel

Described herein are methods of generating a coupled sequencing read pair for a polynucleotide, and methods of analyzing the coupled sequencing read pair. The coupled sequencing read pair can be analyzed to detect polynucleotide variants, including at loci that are not directly sequenced within the coupled sequencing read pair. Other analytical methods can include using coupled sequencing read pairs to construct or validate a consensus sequence. The coupled sequencing read pair may be generated for a polynucleotide by generating sequencing data for a first region by extending a primer using labeled nucleotides; further extending the primer through a second region using nucleotides provided in a second region flow order, wherein primer extension through the second region is faster than primer extension through the first region; and generating sequencing data associated with a sequence of a third region of the polynucleotide by further extending the primer using labeled nucleotides.

Accelerated sequencing methods

The present disclosure provides methods and systems for nucleic acid sequencing. Such systems and methods may achieve context-independent incorporation, have reduced context-dependence or have context-dependence that is amenable to calibration and modeling. Such systems and methods may also reduce misincorporation.

Sequencing using non-natural nucleotides

Recognized herein is the need for methods and processes for increasing the efficiency and accuracy of paired end sequencing.

Methods for processing paired end sequences

The present disclosure provides methods and systems for accurate and efficient context-aware base calling of sequences. In an aspect, disclosed herein is a method for sequencing a nucleic acid molecule, comprising: (a) sequencing the nucleic acid molecule to generate a plurality of sequence signals; and (b) determining base calls of the nucleic acid molecule based at least in part on (i) the plurality of sequence signals and (ii) quantified context dependency for at least a portion of the plurality of sequence signals.

Methods and systems for sequence calling

The disclosure provides methods for sequencing nucleic acids using, including with nucleotide analogs and subsequently appended labels.

Methods and systems for nucleic acid sequencing

Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Methods, devices, and systems for analyte detection and analysis

Multi-operation tools for photovoltaic cell processing are described. In an example, a multi-operation tool includes a conveyor system to move a photovoltaic (PV) cell continuously along a conveyor path through a laser scribing station and an adhesive printing station. Furthermore, the PV cell may be aligned to a laser head of the laser scribing station and a printer head of the adhesive printing station in a single alignment operation prior to being laser scribed and printed with an adhesive in a continuous process.

Multi-operation tool for photovoltaic cell processing

Growing community of inventors

Palo Alto, CA, United States of America

Gilad Almogy