Sanofi-aventis

Sanofi

Synthelabo

Gihad Dargazanli

Genevieve Estenne-Bouhtou

Florence Medaisko

Pierre M Roger

Pascale Magat

Mireille Sevrin

Benoit Marabout

Christian Hoornaert

Ahmed Abouabdellah

Adrien Tak Li

Michele Bas

Corinne Veronique

Nathalie Rakotoarisoa

Benoît Marabout

Maria-Carmen Renones

Geneviève Estenne-Bouhtou

Pascal George

Yannick Evanno

Jonathan Reid Frost

Patrick Andre Lardenois

The invention relates to use of compositions in therapeutics containing a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein.

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A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics

This invention discloses and claims a compound of general formula (I) in which Rrepresents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, Rrepresents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy

Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.

Derivatives of N-[phenyl(alkylpiperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

The disclosure relates to a compound of formula (I): wherein m, n, Ar, and R are as defined in the disclosure, to compositions containing them and to their therapeutic use. The disclosure also relates to processes for preparing these compounds and to certain intermediate compounds.

Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof

Derivatives of N-phenyl (piperidine-2-yl) methyl benzamide, preparation method thereof and applications of same in therapeutics

Derivatives of N-[phenyl(pyrrolidine-2-YL)methyl]benzamide and N-[(azepan-2-YL) phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics

The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics

The present invention discloses and claims a compound of general formula (I) wherein A, X and Rare as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications.

N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy

The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics

Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine.

Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia

N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C&#x2013;C)cycloalkyl-O&#x2014; or (C&#x2013;C)cycloalkyl(C&#x2013;C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl, (C&#x2013;C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

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Cachan, France

Gihad Dargazanli