Vermillion Corporation

University Hospital Ostrava

Csts Health Care Inc.

Giannoula Lakka Klement

Tai-Tung Yip

Judah M Folkman

Edward Rietman

Vladimir Podust

William E Rich

Hana Klosova

Vaclav Prochazka

Edward A Rietman

A method to select a protein target for therapeutic application includes accessing genomic information and protein-protein interaction (PPI) data, computing a thermodynamic measure for each protein node within the network of protein nodes, generating an energy landscape data corresponding to the network of protein nodes and the thermodynamic measure, generating a PPI subnetwork by applying a topological filtration to the energy landscape data of the PPI data, computing a first Betti number for the PPI subnetwork, sequentially removing a protein node(s) from the PPI subnetwork while replacing the previously removed node(s), computing a new Betti number for the PPI subnetwork with the protein node(s) removed, computing a change between the Betti numbers, and determining, based on the change between the Beti numbers, a most significant protein target within the PPI subnetwork.

Thermodynamic measures on protein-protein interaction networks for cancer therapy

This document provides methods and materials involved in treating burn injuries. For example, methods and materials for using skin grafts (e.g., autologous skin grafts) treated with an autologous platelet concentrate and autologous thrombin to treat burn injuries (e.g., deep skin burn injuries) are provided.

Treating burn injuries with reduced hypertrophic scarring

The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.

Platelet biomarkers for cancer

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Giannoula Lakka Klement