Sigea S.r.l.

Imunoloski Zavod

Other

Siega S.r.l.

Innovation Factory S.r.l.

Fondazione Carlo E Dirce Callerio Onlus

Gianni Sava

Giovanni Mestroni

Enzo Alessio

Alberta Bergamo

Jelka Tomasic

Branka Vranesic

Ivo Hrsak

Darko Kantoci

Sonia Zorzet

Dario Voinovich

Stanislav Smerdel

Moreno Cocchietto

Laura Zorzin

Elisabetta Iengo

Stanislay Smerdel

The present invention relates to a method for the production of micro-particles of polysaccharides. The method includes preparing a feeding solution and a gelifying liquid to collect nebulized jets of the feeding solution. The feeding solution contains at least one polymer capable of forming micro-particle structures and at least one biologically active substance. The feeding solution is pressurized inside an air-less nebulizing unit and then nebulized through the unit itself so as to generate nebulized jets impacting the surface of the gelifying liquid.

Method and apparatus for preparing micro-particles of polysaccharides

A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The preparation process includes the use of starting complexes of ruthenium (III) which are reacted with suitable reagents so as to obtain complexes containing NNO coordinated to ruthenium (II). Additional substitution reactions allow the introduction of new groups that coordinate to the ruthenium atom, among which some nitrogen ligands.

Anionic and neutral complexes of ruthenium (II) with nitrogen oxide

A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The preparation process includes the use of starting complexes of ruthenium (III) which are reacted with suitable reagents so as to obtain complexes containing NO coordinated to ruthenium (II). Additional substitution reactions allow the introduction of new groups that coordinate to the ruthenium atom, among which some nitrogen ligands.

New ruthenium dimeric complexes with high antimetastatic and antitumour activity and remarkable chemical stability are described.

Ruthenium dimeric complexes suitable as antimetastatic and antineoplastic agents

A salt of an anionic complex of Ru(III) with an ammonium cation fof formula (I),

Salts of anionic complexes of RU(III), as antimetastatic and antineoplastic agents

2-Adamantyl- and 1-adamantyl-D/L-glycyl-L-alanyl-D-isoglutamine and their derivatives of the formulae ##STR1## wherein R stands for a hydrogen atom or a MurNAc group, and hydrochlorides thereof, a process for the preparation thereof and their use to obtain pharmaceuticals, which are particularly indicated for the treatment of viral diseases and tumors and/or immunomodulations in humans and animals.

New adamantyl comprising tripeptides, derivatives and hydrochlorides

Adamantyl comprising tripeptides, derivatives and hydrochlorides

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Trieste, Italy

Gianni Sava