Cell Therapeutics, Inc.

Cell Therapeutics, Inc. - Sede Secondaria

Gianluca Pardi

Mario Grugni

Ernesto Menta

Alberto Bernareggi

Sergio De Munari

Marco Artico

Marc J McKennon

Paolo Pavesi

Giovanni Da Re

Giulio Mariotti

Gabriella Pezzoni

Paolo Nicoli

Luca Feliciotti

Paola Nicoli

Marc Mckennon

A compound of general formula (I): in which: R is selected from the group consisting of (C-C)alkyl, (C-C)alkenyl, aryl, (C-C)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of &#x2014;B&#x2014;, &#x2014;B&#x2014;(CH)&#x2014;B&#x2014;, &#x2014;B&#x2014;(CH)&#x2014;B&#x2014;(CH)&#x2014;B&#x2014;, wherein r and z are an integer from 2 to 8, B is a &#x2014;NR&#x2014; or &#x2014;N(R)1/pQgroup, in which R1 is selected from hydrogen, (C-C)alkyl, (C-C)acyl, tert-butoxycarbonyl, and Ris selected from hydrogen and (C-C)alkyl; Qis an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, RCOOwherein Rhas the same meanings as R, independently from one another and R&#x2014;O&#x2014;SOwherein Ris (C-C)alkyl with the proviso that, when Qis selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C-C)alkyl. 

Bis-platinum complexes with antitumor activity

The invention relates to an improved process for the preparation of poly-&#x3b1;-glutamic acids which comprises the polymerization of tertiary &#x3b3;-esters of &#x3b1;-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-&#x3b1;-glutamic acid-&#x3b3;-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-&#x3b1;-glutamic acid. The invention also relates to poly-&#x3b1;-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.

Process for the preparation of poly-&#x3b1;-glutamic acid and derivatives thereof

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Ripafratta, Italy

Gianluca Pardi