UniversitÁ Degli Studi Di Genova

Centro Biotecnologie Avanzate

Universita Degli Studi De Genova

Gianluca Damonte

Enrico Millo

Umberto Benatti

Antonio De Flora

Elena Zocchi

Ugo Valbusa

Lucrezia Guida

Luisa Franco

Annalisa Salis

Santina Bruzzone

Giovanna Basile

Gilberto Filaci

Francesco Indiveri

Orazio Taglialatela-Scafati

Ernesto Fattorusso

Vincenzo Ierardi

Francesca Ferrera

Silvia Ravera

Enrico Adriano

Maurizio Balestrino

Patrizia Garbati

A creatine derivative, (Boc)-creatine, is used as a medicament, in particular in a therapeutic antitumor treatment. I (Boc)-creatine.

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A nanoarray or microarray of antibodies includes a planar surface having an ultraflat surface, which has a planar substrate functionalized with a first monolayer of linking molecules, preferably APTES molecules, and a second monolayer of small peptides of the general formula (I) capable of binding the Fc region of antibodies. The nanoarray or microarray includes capture antibodies immobilized on the planar support, preferably in the form of a matrix of spots, and is suitable to be used for detecting antigens in a biological sample by AFM imaging.Z&#x2014;HN&#x2014;R&#x2014;R&#x2014;R&#x2014;R&#x2014;R&#x2014;R&#x2014;NH&#x2014;X&#x2014;CO-G-COOH.

Planar support having an ultraflat surface and a device for detecting antigens comprising said planar support

The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD. 

Adenyl dinucleotides with antitumour activity and a method of preparing thereof

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Arenzano, Italy

Gianluca Damonte