Vivex Biomedical, Inc.

Vivex Biologics Group, Inc.

The United States Government as Represented by the Department of Veterans Affairs

University of Miami

Vivex Biologies Group, Inc.

Gianluca D'Ippolito

Paul C Schiller

Timothy Ganey

Wendy W Weston

Gaëtan Jean-Robert Delcroix

Miguel Quevedo

Stuart Oglesby

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.

Biologic composition and method of manufacture

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.

Acellular biologic composition and method of manufacture

Described herein are post natal, multilineage inducible cells (MIAMI cells). In some examples, the cells are isolated from non fractionated, adult (males and females 3 to 72 years old) human bone marrow under cell culture conditions, which are believed to resemble an in vivo niche microenvironment in which primitive multipotent cells exist. MIAMI cells have a unique profile of molecular markers, and can be maintained in vitro (for more than 50 population doublings) without detectable changes in their characteristic molecular profile. MIAMI cells can be differentiated into mesodermal, neuroectodermal, and endodermal cell lineages. Methods of isolating, differentiating and using MIAMI cells are also described.

Multilineage-inducible cells and uses thereof

Growing community of inventors

North Miami Beach, FL, United States of America

Gianluca D'Ippolito