Sanofi

Crinos Industria Farmacobiologica S.p.a.

Sclavo, Inc.

Crinos Industria Farmabiologica, S.p.a.

Giangiacomo Torri

Benito Casu

Giorgio Zoppetti

Annamaria Naggi

Process for the depolymerization and sulfation of polysaccharides by reaction of said polysaccharides with a sulfuric acid/chlorosulfonic acid mixture.

Process for the depolymerization and sulfation of polysaccharides

Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.

Depolymerized and supersulfated heparin, process for its preparation and

A novel polyaminic resin obtained by crosslinking a polyalkyleneamine (in particular polyethyleneamine) with diisocyanates in solution, is useful as a selective separation or extraction agent of a component having a 'complementary' chemical structure (particularly heparin), by means of mere contact or 'ionic exchange' with aqueous solutions containing it. Heparin is thus even quantitatively extracted from solutions containing it alone or in mixture with other glucosaminoglycanes. The polyamine can then release the 'adsorbed' heparin and be recovered by a treatment with saline solutions. The novel resin is used in pharmaco-biological fields.

Polyaminic resin for the selective separation of heparin from other

Polyalkylene resins crosslinked with diisocyanate used for selective

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Bergamo, Italy

Giangiacomo Torri