Alchemia Limited

Giang Thanh Le

Wim F Meutermans

Giovani Abbenante

Wim Meutermans

Michael Leo West

Giovanni Abbenante

Gerald B Tometzki

Karl Schafer

Johannes Zuegg

Tracie E Ramsdale

Nicholas B Drinnan

Ligong Liu

George Adamson

Craig Muldoon

Bernd Becker

Matthias Grathwohl

Premraj Rajaratnam

Peter Andrews

Chris Clark

Declan McKeveney

Rajaratnam Premraj

Tracie Elizabeth Ramsdale

Nicholas Barry Drinnan

New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .

Derivatives of monosaccharides for drug discovery

The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein: 

Antibacterial agents

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

Disaccharides for drug discovery

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Mt. Gravatt, Australia

Giang Thanh Le