Universitá Degli Studi Di Padova

Tel Aviv University

Nof Corporation

Gianfranco Pasut

Hiroki Yoshioka

Ronit Satchi-Fainaro

Midori Hirai

The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.

Conjugate of bio-related substance and block polymer, and block polymer derivative for obtaining said conjugate

Polymeric conjugates comprising a polymeric backbone having attached thereto a bone targeting moiety and a therapeutically active agent, wherein the bone targeting moiety is attached to one end of the polymeric backbone via a branching unit such that a molar ratio of the bone targeting moiety to the polymer is at least 2:1, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

Growing community of inventors

Padua, Italy

Gianfranco Pasut