Gruppo Lepetit

Giancarlo Volpe

Bruno Cavalleri

Hermes Pagani

Giancarlo Lancini

Alessandro Assandri

The present invention relates to a glycopeptide antibiotic arbitrarily designated as A/16686 antibiotic, and to its physiologically-acceptable acid addition salts. Antibiotic A/16686 free base, and its acid addition salts are antibacterial agents, especially active against grampositive microorganisms. The process for producing antibiotic A/16686 by culturing a novel strain of the actinoplanes genus, designated as Actinoplanes sp. ATCC 33076, is a further object of the present invention.

Biologically pure culture of actinoplanes capable of producing

The present invention relates to a glycopeptide antibiotic arbitrarily designated as A/16686 antibiotic, and to its physiologically-acceptable acid addition salts. Antibiotic A/16686 free base, and its acid addition salts are antibacterial agents, especially active against grampositive microorganisms. The process for producing antibiotic A/16686 by culturing a novel strain of the Antinoplanes genus, designated as Actinoplanes sp. ATCC 33076, is a further object of the present invention.

Antibiotic A/16686 and process for preparation thereof

2-Nitroimidazole derivatives of the following formula: ##STR1## wherein R is benzoyl, phenylcarbamoyl or the group ##STR2## wherein R.sub.1 is C.sub.1-4 alkyl, ##STR3## in which R.sub.2 is hydrogen, halo, cyano, amino, C.sub.1-2 alkyl, or C.sub.1-3 alkoxy and X is oxygen or sulfur. These compounds have antimicrobial and amoebicidal utilities.

2-Nitroimidazole derivatives

The compound 5-[(1-hydroxy-1-methyl)ethyl]-1-methyl-2-nitroimidazole is valuable in combatting Trichomonas vaginalis infections in mammals.

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Milan, Italy

Giancarlo Volpe