Glaxo Group Limited

Giancarlo Trani

Christopher Norbert Johnson

Andrew Kenneth Takle

David Kenneth Dean

Steven James Stanway

Aaron Bayne Miller

Daryl Simon Walter

David Timothy Macpherson

Jorge Munoz-Muriedas

Mairi Sime

Jon Graham Anthony Steadman

Rachel Elizabeth Anne Thewlis

Xi Liang

David G Jones

Ian David Wall

Antoinette Naylor

Antoinette Wilson

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, Calkyl, Ccycloalkyl, Calkoxy, Calkoxy Calkyl, Cfluoroalkyl, halogen, NRR, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R, R, R, R, R, Rand Rare as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis or osteoarthritis or neurodegenerative disorders.

5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine derivatives as P2X7 modulators

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein A is hydrogen, Calkyl, Ccycloalkyl, Calkoxy, Calkoxy Calkyl, Cfluoroalkyl, halogen, NRR, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R, R, R, R, R, Rand Rare as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators

The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.

Indazoles used to treat estrogen receptor beta mediated disorders

The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.

Compounds

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Harlow, United Kingdom

Giancarlo Trani