Nogra Pharma Limited

Giuliani International Limited

Giancarlo Naccari

Sergio Baroni

The present invention relates to compounds comprising the general formula (I), in which Rand R, which may be identical or different, are selected from the group comprising &#x2014;H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising &#x2014;H, &#x2014;OH, &#x2014;COOH, &#x2014;OR, &#x2014;CH(OR)COOH, in which Ris selected from H, phenyl, benzyl, &#x2014;CFor &#x2014;CFCF, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field

The present invention relates to compounds comprising the general formula (I), in which Rand R, which may be identical or different, are selected from the group comprising &#x2014;H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms, Y and Z, which may be identical or different, are selected from the group comprising &#x2014;H, OH, &#x2014;COOH, &#x2014;OR, &#x2014;CH(OR)COOH, in which Ris selected from H, phenyl, benzyl, CF, or CFor CFCF, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.

The present invention relates to compounds comprising the general formula (I), in which Rand R, which may be identical or different, are selected from the group comprising &#x2014;H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising &#x2014;H, &#x2014;OH, &#x2014;COOH, &#x2014;OR, &#x2014;CH(OR)COOH, in which Ris selected from H, phenyl, benzyl, &#x2014;CFor &#x2014;CFCF, vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms. 

The present invention relates to compounds of formula (I), where Rand R, which may be identical or different, are selected from the group comprising H, CH, a linear or branched alkyl group having 1 to 6 carbons, or together form an aromatic or aliphatic ring with 5 or 6 atoms; Ris &#x2014;CO&#x2014;CH, &#x2014;NHOH, &#x2014;OH, or &#x2014;ORwhere Ris a linear or branched alkyl group having 1 to 6 carbon atoms; R4 is H, linear or branched alkyl group having from 1 to 6 atoms, phenyl, benzyl, &#x2014;CFor CFCF, vinyl or allyl; R, R, Rare hydrogen atoms; or Rand R, Rand R, or Rand Rtogether form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O, and use thereof in the medical field.

Compounds and their salts specific to the PPAR receptors and the EGF Receptors and their use in the medical field

The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either single or double and wherein R1, R2, R3, R4 or R5, equal or different between each other, have general formula -(Int)-Ter, wherein m is between 0 and 12 and Int and Ter are Internal and Terminal building blocks, wherein Int is selected from the group consisting of formula (II); and Ter is selected from the group consisting of formula (III). And wherein X represents either carbon or nitrogen atom within aromatic ring, Y represents either oxygen or sulphur atom and an additional group Q, group Qi or groups Qi (Qi indicates that the group or several groups may be bound to any unsaturated moiety of the ring) are selected from the group consisting of &#x2014;OH, &#x2014;COOH, &#x2014;N(CH), &#x2014;N(CH&#x2014;CH)|&#x2014;CO&#x2014;CH, &#x2014;CO&#x2014;O&#x2014;CH, &#x2014;O&#x2014;CH, &#x2014;S&#x2014;CH, &#x2014;SO&#x2014;CH, &#x2014;CN, &#x2014;NOor -Halogen elements, and wherein R5 may be formula (IV) and metal and ammonium salts thereof, wherein n is between O and 5, or oxygen or phosphorus is partially or completely replaced by nitrogen, sulphur, methyleno groups or their derivatives. The invention also concerns the uses of the above mentioned compounds in medical field and the process for their preparation. 

Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation

Therefore the present invention relates specifically to the compounds of general formula (I), in which Rand R, which may be identical or different, are selected from the group comprising H, &#x2014;CH, a linear or branched alkyl group having from 1 to 6 carbon atoms, or together form an aromatic or aliphatic ring with 5 or 6 atoms; Ris selected from &#x2014;CO&#x2014;CH, &#x2014;NHOH, &#x2014;OH, &#x2014;ORin which Ris a linear or branched alkyl group having from 1 to 6 carbon atoms; Ris selected from H, a linear or branched alkyl group having from 1 to 6 carbon atoms, phenyl, benzyl, &#x2014;CFor &#x2014;CFCF, vinyl or allyl; R, R, Rare hydrogen atoms; or Rand R, Rand R, or Rand Rtogether form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O. and use thereof in the medical field. 

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Monza, Italy

Giancarlo Naccari