Universidad Miguel Hernández De Elche

Universita Degli Studi Del Piemonte Orientale "amedeo Avogadro"

Universtà Degli Studi Di Torino

Kither Biotech Srl

Gian Cesare Tron

Antonio Vicente Ferrer Montiel

Salvatore Cuzzocrea

Emilio Hirsch

Armando Genazzani

Tracey Pirali

Juana Gallar Martinez

Asia Fernandez Carvajal

Carlos Belmonte Martinez

Elisa Ciraolo

Valentina Mercalli

Giovanni Sorba

Ubaldina Galli

Alberto Massarotti

Roberto De La Torre

Pier Luigi Canonico

Armando A Genazzani

Cristina Travelli

Giorgio Grosa

The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C-C) alkyl; b) optionally substituted (C-C) cycloalkyl; c) optionally substituted (C-C) aryl; d) optionally substituted (C-C) heteroaryl; e) C(O)&#x2014;(C-C) aryl, in which group (C-C) aryl is optionally substituted; f) C(O)&#x2014;(C-C) heteroaryl, in which group (C-C) heteroaryl is optionally substituted; g) CH(OH)&#x2014;(C-C) aryl, in which group (C-C) aryl is optionally substituted; and h) CH(OH)&#x2014;(C-C) heteroaryl, in which group (C-C) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.

TRPM8 receptor agonist compounds and uses thereof

Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity. 

Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases

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Novara, Italy

Gian Cesare Tron