Zambon Group

Gian Carlo Grancini

Dario Chiarino

Angelo Carenzi

Mauro Napoletano

Viviana Frigeni

Carlo Veneziani

Francesco Santangelo

Davide Della Bella

Stefania Montanari

Paolo Cavalleri

Cristina Fraire

Compounds of formula ##STR1## wherein R, R', R', R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are described. The compounds of formula I are useful in the treatment of arterial hypertension and congestive heart failure, of renal failure, of peripheral arteriopathies, of cerebrovascular insufficiencies and of ischemic cardiopathy.

Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the

A stereoselective process for the preparation of the compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, a and b have the meanings reported in the specification, is described. The compounds of formula I have a remarkable central analgesic activity and they are useful in the pharmaceutical field.

Stereoselective process for the preparation of 2-amino-ethanol

Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3 and n have the meanings reported in the specification), their salts with pharmaceutically acceptable acids, process for their preparation and pharmaceutical compositions containing them are described. The compounds of formula I have a remarkable analgesic activity.

Pyrrolidone-2 compounds and their use for central analgesic activity

Compounds of formula ##STR1## (wherein R, R.sub.1 and R.sub.2 have the meanings reported in the specification) and their preparation are described. The compounds of formula I have anti-allergic, anti-anaphylactic and anti-arthritic activity and are useful in pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

4-(3-Coumarinyl)-thiazole-derivatives with anti-allergic,

Compounds of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) and their preparation are described. The compounds of formula I have anti-allergic, anti-anaphylactic and anti-arthritic activity and are useful in pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.

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Nova Milanese, Italy

Gian Carlo Grancini