L. Molteni & C. Dei Fratelli Alitti—società Di Esercizio S.p.a.

Molteni Therapeutics S.r.l.

L. Molteni & C. Dei Fratelli Alitti

L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni

Giacomo Chiti

Gabrio Roncucci

Donata Dei

Lia Fantetti

Daniele Nistri

Valentina Paschetta

Annalisa Cocchi

Francesca Giuntini

Giulio Jori

Francesco Giuliani

Moira Municchi

Maria Paola De Filippis

Gian Maria Rossolini

Salvatore Demartis

Daniela Monti

Silvia Tampucci

Marco Possenti

Stefano Mascheroni

Paolo Sarri

Clara Fabris

Yann Raoul

Aldo Hendrikus Velders

Carmela Alongi

The present invention describes topical formulations for use in photodynamic therapy (PDT) of skin affections, said formulations comprising a Zn-phthalocyanine derivative.

Topical formulations containing phthalocyanine photosensitizers

There is described a phthalocyanine derivative of formula (I) consisting of 4 isomers wherein the relative isomer B content is less than or equal to 1% by weight. 

Phthalocyanine derivative consisting of a mixture of 4 isomers

Self-sterilising products, and in particular novel products comprising phthalocyanine derivatives bound to polymers, a process for the preparation of said products and their use for preparing self-sterilising industrial and medical articles or devices, are described.

Self-sterilizing products

The present invention relates to pharmaceutical compositions comprising metal phthalocyanine analogues of formula (I) and metal chelating compounds having a good bioavailability and enhanced photoinactivation properties against Gram negative bacteria; and to their use for in vivolex vivo applications, such as blood and blood derivatives sterilization. 

Antibacterial compositions comprising metal phthalocyanine analogues

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described.

Meso-substituted porphyrins

A process is described for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group, products useful as photosensitizing agents in photodynamic therapy.

Process for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group

Phthalocyanine derivatives are described having photosensitizing characteristics and high solubility in water, useful for photodynamic treatment of bacterial infections, in particular infections generated by Gram-negative bacteria.

Phthalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described. 

The present invention relates to metal-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the axial positions of metal-phthalocyanine nucleus; moreover it refers to the process for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies in PDT and/or BNCT.

Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof

The present invention relates to meta 1-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the peripheral positions of meta 1-phthalocyanine nucleus; moreover it refers to the processes for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies.

The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as phototherapeutic and photodiagnostic agents 

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Montemurlo, Italy

Giacomo Chiti