Council of Scientific and Industrial Research

Other

Colgate Palmolive Company

Indian Institute of Integrative Medicine

Chitaranjan National Cancer Institute

Ghulam Nabi Qazi

Subhash Chandra Taneja

Naresh Kumar Satti

Krishan Avtar Suri

Vijeshwar Verma

Om Parkash Suri

Rakesh Kamal Johri

Kasturi Lal Bedi

Subhash Chander Sharma

Surrinder Koul

Bishan Datt Gupta

Ashok Kumar Tikoo

Bal Krishan Kapahi

Inshad Ali Khan

Bal Krishan Chandan

Ashwani Kumar

Vijay Kumar Sethi

Bupinder Singh Jaggi

Ravinder Kumar Raina

Samar Singh Andotra

Manoj Kumar Tikoo

Pankaj Gupta

Ravi Kant Khajuria

Sukhdev Swami Handa

Rakesh Maurya

Anamika Khajuria

Suresh Chandra

Ravi Subramanyam

Brijesh Kumar

Laurence Du-Thumm

Furqan Ali

Rakesh Tuli

Ajit Kumar Saxena

Ajay Kumar Singh Rawat

Shanta Mehrotra

Govindarajan Raghavan

Jawahir Lal Koul

Kanaya Lal Dhar

Rajender Singh Sangwan

Dilip Manikrao Mondhe

Vikram Bhardwaj

Nitin Pal Kalia

Neelam Singh Sangwan

Vishwa Nath Gupta

Girish Chandra Uniyal

Subha Rastogi

Sayyada Khatoon

Vijai Kant Agnihotri

Shashank Kumar Singh

Zahid Mehmood Mirza

Monika Pandita

Lila Ram Manhas

Anita Khosa

Surjit Singh

Ashok Kumar Shahi

Prabhu Dutt

Satish Chander Puri

Satya Narayan Sharma

Geeta Handa

Sheikh Tasaduq Abdullah

Ashok Ahuja

Sushma Koul

Brij Lal Kaul

Navin Kumar Verma

Neelam Sharma

Om Prakash Suri

Kuldeep Singh

Vinay Gupta

Avdhesh Kumar Srivastava

Devinder Kumar Gupta

Bal Krishnan Kapahi

Gurdarshan Singh

Narayan Das Chaurasiya

Laxmi Narayan Misra

Payare Lal

Jyotsna Suri

Sheikh Tasaduq Absullah

Madalsa Bargotra

Shri Gopal Agarwal

Rajinder Kumar Thappa

Naveen Anand

Munish Kapoor

Rattan Lal Sharma

Syed Riyaz-Ul-Hassan

Satinder Mohan Jain

Musarat Amina

Surrinder Kumar Lattoo

Avtar Krishan Dhar

Paresh Purohit

Rekha Sapru Dhar

Mahrak Krishen Kaul

Sanotosh Kumar Bakshi

Maharaj Krishan Koul

Abid Zaffar Hashmi

Shubash Chandra Taneja

Krishnan Avtar Suri

Touseef Amna

Ram Vilas Parsad Sinha

Rajinder Kumar Khajuria

Neelam Verma

Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.

Chalcones as enhancer of antimicrobial agents

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2 (E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Aromatic amides as potentiators of bioefficacy of anti-infective drugs

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)&#x2014;N-benzyl-3-hydroxypyrrolidine and (R)&#x2014;N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)&#x2014;N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines

The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.

Synergistic hepatoprotective composition and a method thereof

The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising:

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The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis of Camptothecin (camptothecinoids).

Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same

The present disclosure relates to methods and compositions for in vitro cultivation of species of, e.g.(Ham.). The disclosure provides culture media comprising Murashige and Skoog (MS) basal culture medium, plant hormones preferably selected from the group consisting of benzyladenine (BAP), gibberellic acid (GA), and auxins, and other additives, e.g. sucrose and agar. Preferably, auxins are selected from the group consisting of indole acetic acid (IAA), indole butyric acid (IBA), and naphthalene acetic acid (NAA). Individual plant hormone concentrations are preferably from about 0.5 mg/L to about 5.0 mg/L. The disclosure provides methods of in vitro cultivation ofcomprising contacting preferably axillary bud and/or shoot apex explants with an initiation medium comprising a modified MS basal culture medium, BAP, IAA, IBA, and NAA to produce a primary explant, contacting the primary explant with a shoot propagation medium comprising, a modified MS basal culture medium, BAP, GA, and IAA to produce a secondary explant, contacting a secondary explant with a rooting medium comprising a modified MS basal culture medium, IAA, IBA, and NAA. The methods and compositions of the invention are capable of inducing extraordinarily rapid in vitro propagation of. The methods and compositions of the disclosure may be useful for conservation of this threatened species as well as producing bulk quantities, e.g. gram, kilogram or more, of plant material for medicinal

The present invention relates to a process for the synthesis of racemic nerol oxide i.e. 3,6-dihydro-4-methyl-2-[2-methyl-1-propenyl)-2H-pyran from monoterpene alcohol nerol i.e. cis-3,7-dimethylocta-2,6-diene-1-ol.

Process for preparation of nerol oxide

The present invention relates to a novel synthetic process for the enriched preparation of substituted R(+)&#x3b2;-benzyl-&#x3b3;-butyrolactone (1) as shown in the drawing wherein Rand Rindependently or in combination represent the following groups: i.e. R&#x2550;R&#x2550;H, &#x2014;OCH(where n=1 to 8); R, and Rtogether represents &#x2014;O(CH)O&#x2014; (where m=2 to 4) 

Chemo-enzymatic process for the preparation of opticaly enriched &#x3b2;-benzyl-&#x3b3;-butyrolactones

The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

Use of herbal agents for potentiation of bioefficacy of anti infectives

The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from(Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.) (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol in the alcohol-water mixture for fresh plant material, the invented extractant composition leading to better/improved yields and accurate quantitative estimations of withaferin A existent in planta or in materia, selecting effective state of the tissue particularly use of the fresh materials improving yields, providing logistic benefits of isolations and diagnosis, and according several other advantages including technological, economic, preventing contaminations etc., the said method being valuable and advantageous for standardization of botanicals, metabolomic characterization of plants particularly chemotypes, analyzing metabolic transitions under physiological, genetical, environmental and biotic perturbations.

Process for isolation of withaferin-A from plant materials and products therefrom

The present invention relates to an efficient method for the extraction of high stability, superior quality, value added, standardized, ready-to-use saffron pigments and flavor concentrate, the process comprising steps of mixing saffron with one food-grade solvent or a combination of more than one food graded-solvents, macerating and agitating the mixture with continuance protection from light condition, centrifuging the macerated mixture to remove undesirable fibrous plant material, cooling the centrifuge immediately, lyophilizing the cooled centrifuge under reduced pressure to obtain crude material, isolating the concentrate by column chromatography, and obtaining brilliant orange color shining saffron pigments and flavor concentrate with recovery of about 95%, and use of the saffron pigments and flavor concentrate of range between 0.05 to 3% in food, pharmaceutical, and allied industries for flavor, and color.

Method for the extraction of saffron pigments and flavor concentrate

The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phenylglycidate i.e. alkyl(2S,3R)-phenylglycidate and alkyl(2R,3S)-phenylglycidate of formulae 7 and 8 respectively 

Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain

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Jammu, India

Ghulam Nabi Qazi