William H. Rorer, Inc.

American Home Products Corporation

Rorer Pharmaceutical Corporation

American Home Products Corporation (del.)

Ghulam N Mir

John Yelnosky

George H Douglas

Chong M Won

William L Studt

William Alvin Kinney

Amadeo A Failli

Dahyabhai M Patel

Ronald L Alioto

Gerald L Reuter

John Francis DiJoseph

Luis E Borella

Jacqueline B Krebs

There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.

2-pyridinecarbothioamides, processes for preparation thereof

2-pyridinecarbothioamides and pharmaceutical compositions comprising the

There are provided gastric cytoprotective exogenously acidified aluminum hydroxide antacid compositions which are formed by acidifying, for example, commercial liquid antacid suspensions containing aluminum hydroxide, antacid powders or solids containing aluminum hydroxide, or aluminum hydroxide gel, to the point where the aluminum hydroxide is solubilized. The solutuions may be formulated into liquid dosage forms or spray dried and formulated into solid dosage forms.

Exogenously acidified antacid compositions having cytoprotective

1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of Irritable Bowel Syndrome.

Amidinoureas for treating irritable bowel syndrome

Amidinoureas are disclosed as useful for the treatment of irritable bowel syndrome.

1-Phenyl-3N-alkyl amidinoureas are useful in the treatment of irritable bowel syndrome.

Amidinoureas of the formula: ##STR1## when administered to females who suffer dysmenorrhea relieve discomfort and pain and prevent damage caused by abnormal uterine muscle spasms incident to dysmenorrhea.

Dysmenorrhea treatment

New compositions containing as the principle active ingredient a 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-one are used for remedial or prophylactic treatment of diarrhea and organic gastrointestinal disorders accompanied by diarrheal symptoms.

Antidiarrheal triazinones

1,4-disubstituted-1,2-dihydro-1,3,5-triazine-2-ones and their pharmaceutically acceptable salts are used in the prevention and treatment of gastrointestinal disorders associated with hyperactivity of the secretory glands in the gastrointestinal tract.

Antisecretory triazinones

1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-ones and their pharmaceutically acceptable salts are used in the control of abdominal spasticity especially the treatment of spasmodic conditions of the gastrointestinal tract by administering an effective amount of the triazinone in suitable pharmaceutical dosage forms including oral or parenteral dosage forms compounded with pharmaceutically acceptable carrier materials to patients having spasmodic syndromes.

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Buckingham, PA, United States of America

Ghulam N Mir