Medtronic Percusurge, Inc.

Surface Genesis, Inc.

Medtronic Ave, Inc.

Percusurge, Inc.

Gholam Reza Zadno-Azizi

Ketan P Muni

Celso J Bagaoisan

Mir A Imran

Raj Subramaniam

Samuel L Omaleki

Richard P Geoffrion

A method for the treatment of a stenosis or an occlusion in a blood vessel in which an occlusive device is first delivered and activated at a site distal to the occlusion to at least partially occlude the vessel. A therapy catheter is then introduced to treat the occlusion and a debris removal device is delivered to aspirate debris from the vessel. The present invention eliminates the need for a separate irrigation catheter and irrigation fluid which allows the procedure to be performed quickly and efficiently, and is especially useful in the removal of occlusion from saphenous vein grafts, the coronary and carotid arteries, arteries above the aortic arch and vessels of similar size and pressure.

Aspiration method

A method for the treatment of a stenosis or an occlusion in a blood vessel in which an occlusive device is first delivered and activated at a site distal to the occlusion to at least partially occlude the vessel. A therapy catheter is then introduced to treat the occlusion and a debris removal device is delivered to aspirate debris from the vessel. The present invention eliminates the need for a separate irrigation catheter and irrigation fluid which allows the procedure to be performed quickly and efficiently, and is especially useful in the removal of occlusion from saphenous vein graft, the coronary and carotid arteries, arteries above the aortic arch and vessels of similar size and pressure.

A radiation delivering catheter is positioned away from the walls of the vessel to be treated, e.g. at a stenosis site, so that the radiation flux impacting the walls is more uniform. In one embodiment, one or more balloons are used, and in another, one or more expandable structures. In other embodiments, a radiation source residing within a balloon is shielded from the vessel walls when the balloon is not inflated, but exposes the vessel walls to radiation when the balloon is inflated.

Intravascular radiation therapy device and method of use

A composite structure comprising a body having a surface. Cladding covers at least a part of the surface. The body and the cladding are formed of different materials, at least one of which is a shape memory alloy having a recoverable strain in excess of 1.0%.

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Newark, CA, United States of America

Gholam Reza Zadno-Azizi