National Science Council

Academia Sinica

Gholam H Hakimelahi

Jih Ru Hwu

Shwu-chen Tsay

Chun Chieh Lin

Wen Nan Tseng

Abdolmajid Azaripour

Shwu-Chen Tsay

Hasan Mottaghian

Ali A Moshfegh

Majid M Sadeghi

Ali A Moosavi-Movahedi

Antiviral compounds

A series of phloroglucide derivatives are synthesized, which possess potent antibacterial activities. They include unsymmetrical phloroglucide analogs, phloroglucides attached to cephalosporins at the C-3&prime; position, and 7-(phloroglucidamido)cephalosporins.

Phloroglucidic acid and derivatives as antibacterial agents

A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH.sub.2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts thereof, and an antibacterial pharmaceutical composition derived thereof.

Phloroglucide derivatives and their pharmceutical use

Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): ##STR1## wherein R.sup.1 is hydrogen, cyano (--CN), halogen or azido (--N.sub.3); R.sup.2 is hydroxyl or an amino ester radical having a formula of --NHR.sup.4 COOR.sup.5, wherein R.sup.4 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.5 is C.sub.1 -C.sub.4 alkyl; Me is methyl; and R.sup.3 is hydroxyl or thymidinyl having a formula as follows: ##STR2##

Thymidylate analogs and the use thereof

Novel adenylate analogs having the following formula are synthesized in the present invention, which are found active against herpes simplex viruses: ##STR1## wherein R.sup.1 is hydroxyl, C.sub.1 -C.sub.4 alkoxy, an amino ester radical of --NHR.sup.3 COOR.sup.4, wherein R.sup.3 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.4 is C.sub.1 -C.sub.4 alkyl; and R.sup.2 is hydroxyl, --O.sup.+ NH.sub.4 or ##STR2##

Adenylate analogs as potent anti-herpes virus agents

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Taipei, Taiwan

Gholam H Hakimelahi