Cis Bio International

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université´ D'aix-marseille

Institut Jean Paoli & Irène Calmettes

Cisbio Bioassays

Universitè De Montpellier

Université Paris—sud

Cis Bio International French Joint Stock Company

Institut Gustave Roussy

Gérard Mathis

Eric Trinquet

Hervé Bazin

Daniel Baty

Patrick Chames

Jean-Philippe Pin

Damien Nevoltris

Michel Fink

Jurriaan Zwier

Fabrice Andre

Iris Pribilla

Patrick Garnero

Hervé Ansanay

Norbert Tinel

Michel Laget

Thierry Durroux

Achim Brinker

Emmanuel Claret

Pauline Scholler

Sraboni Ghose

Patrizia Alberti

Philippe Rondard

The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.

Anti-EGFR conformational single domain antibodies and uses thereof

The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single domain antibodies and uses thereof in particular in the therapeutic and diagnostic field.

Anti-mGluR2 conformational single domain antibodies and uses thereof

The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one or two FRET partner pairs.

Method for determining the binding of a given compound to a membrane receptor

Method for the detection in homogeneous medium of a post-translational modification of a proteinaceous substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the proteinaceous substrate and a first coupling domain and in that it comprises the following stages:

Method for the detection of post-translational modifications

The invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules in living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.

Method for detecting intracellular interaction between biomolecules

The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium.

Method for suppressing a FRET signal, FRET signal suppressor agents and use in a method for multiplexing biological events

The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.

Inositol-phosphate derivatives and method of detecting inositol-1-phosphate

The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps:

Method of revealing a biological process using a FRET measurement

The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium.

Method for improving the detection of fluorescence signals during a resonance energy transfer

The invention relates to a homogeneous method for detecting and/or determining by fluorescence a chemical or physicochemical interaction in a measuring medium, in which a rare-earth metal cryptate comprising a substituent is used, characterized in that the variation of at least one fluorescence characteristic of the rare-earth metal cryptate, induced by the change in the physicochemical properties of the substituent resulting from said interaction, is measured.

Homogeneous detection and/or determination method for a chemical or physico-chemical interaction

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Bagnols sur Ceze, France

Gérard Mathis