Richter Gedeon Vegyeszeti Gyar Rt

Geza Wack

Karoly Zalai

Eva Udvardy Nagy Nee Cserey Pechany

Lajos T Nagy

Sandor Gorog

Gyorgy Fekete

Janos Kiss

Bulcsu Herenyi

Miklos Budai

Zsuzsa Lengyel Nee Szemenyei

Erzsebet Zsoka Nee Somkuti

The invention relates to a new method for controlling the level and distribution of alkaloids produced by Claviceps purpurea variant strains capable of producing primarily ergocornine, .alpha.-ergocryptine and .beta.-ergocryptine under saprophytic conditions. According to the invention a compound of the biosynthesis path of isoleucine or a compound which promotes the formation of isoleucine by biochemical control is added to the fermentation broth. In other respects fermentation is performed under conditions known per se. By the method of the invention the ratio of .alpha.- and .beta.-ergocryptine formed in the fermentation broth can be adjusted to the optimum value.

Method for controlling the amount and distribution of alkaloids formed

The invention relates to a new process for the preparation of ergot alkaloids, primarily ergocornine and .beta.-ergocryptine, by subjecting a Claviceps purpurea strain to fermentation under aerobic conditions in a culture medium which contains carbon and nitrogen sources, mineral salts and optionally other additives, too. According to the invention a Claviceps purpurea variant strain deposited under No. MNG 00186 is applied as alkaloid-producing strain.

Fermentation process for the preparation of ergot alkaloids, primarily

Growing community of inventors

Budapest, Hungary

Geza Wack