Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Geza Galambos

Gabor Kovacs

Istvan Stadler

Sandor Virag

Jozsef Ivanics

Gyorgy Dorman

Peter S Kormoczy

Vilmos Simonidesz

Istvan Tomoskozi

Peter Gyory

Pal Hadhazy

Karoly Kanay

Csaba Szantay

Gyula Papp

Laszlo Szekeres

Jeno Marton

Lajos Novak

Karoly Kanai

Agnes Papp Nee Behr

Ildiko Szilagyi

Judit Skopal

Peter Kormoczi

Jozsef Aszodi

Peter Kormoczky

Marianna Kovacs

Istvan Tomoskozy

Miklos Kiss

Eva Udvary

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;

Interfuranylene prostacyclins

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

New PGI.sub.1 derivatives are disclosed as well as a process for the preparation thereof, pharmaceutical compositions containing same and methods of treatment employing same. The new compounds are useful to inhibit blood platelet aggregation induced by ADF, arachidic acid, or collagen, as well as to improve blood circulation and to inhibit gastric acid secretion.

5-Substituted-4-oxo-PGI.sub.1 derivatives, PGI.sub.1 compounds of

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms;

13-Thia-prostacycline derivatives

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Budapest, Hungary

Geza Galambos