Nexel Co., Ltd.

Geun Ho An

Jaehun Lee

Jinwoo Chung

Gun Sik Cho

Dong-Hun Woo

Choongseong Han

Hye Ryeon Jeon

Xiong Jin

Tack Jin Yoo

Dong Hun Woo

Jeong Seong Kim

Choong Seong Han

The present application relates to compositions and methods comprising polypeptides derived from MFG-E8 for treating and preventing fibrosis and other diseases.

Compositions and methods for treating or preventing fibrosis

The present invention relates to a recombinant protein for preventing or treating tissue fibrosis, which is based on milk fat globule-EGF factor 8 (MFG-E8) protein and comprises the amino acid sequence of SEQ ID NO: 1, and to a composition for preventing or treating tissue fibrosis, which comprises the recombinant protein. The level of the effect of preventing or treating tissue fibrosis by the recombinant protein of the present invention is significantly improved compared to that of conventional milk fat globule-EGF factor 8 (MFG-E8) protein, so that the level of tissue fibrosis can be restored to a level very close to that in normal tissue by the prevention and treatment of tissue fibrosis.

Recombinant protein for preventing or treating tissue fibrosis and composition for preventing or treating tissue fibrosis comprising the same

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Seoul, South Korea

Geun Ho An