Novartis Ag

Gesine Winzenburg

Christopher Bush

Fabian Chen

Surya Prakash Ayalasomayajula

Olivier Timbal

Bernd Trueby

Masha Berkhin

A dip tube () for extracting a fluid () from a bottle () comprises an adapter () configured to be at least partially inserted into a neck () of the bottle () and being provided with a connecting port () which is configured to be connected to a suction device (), an elongated hollow withdrawal tube () which has a cross-sectional area that is smaller than a cross-sectional area of the adapter () and which is configured to protrude from the adapter () into a fluid receiving space () of the bottle (), when the adapter () is inserted in the bottle neck (), and which is arranged in fluid communication with the connecting port () of the adapter (), and a sealing disc () extending from an outer circumferential surface () of the withdrawal tube () and being configured to abut against an inner surface () of the bottle () so as to seal the fluid receiving space () of the bottle ().

Dip tube

The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.

Galenic formulations of organic compounds

Growing community of inventors

Basel, Switzerland

Gesine Winzenburg